Treatment guide
Polynucleotides
Polynucleotide injectables support skin repair and regeneration — popular for face, under-eye and scalp concerns. Modelow helps you find reduced-price appointments at verified UK clinics.
What do polynucleotides cost in the UK?
Polynucleotide pricing is usually per session or course. Based on advertised prices reviewed across UK clinics in September 2026, sessions commonly fell around £175–£450, with three-session courses often £550–£650. These are general market ranges — not Modelow prices.
General UK market guidance — not Modelow prices
| Typical UK pricing | Guide range |
|---|---|
| Face — single session | Commonly around £175–£300Lír Aesthetics from £175; ZOLU £250; Eternal Glow £220. |
| Under-eye / periorbital | Commonly around £175–£250 per sessionEye area is a common entry point; often priced at lower end of range. |
| Course of 3 (face) | Commonly around £550–£650ZOLU £650; Eternal Glow £550; Lír Aesthetics up to £450 per session tier. |
| Course of 2 | Commonly around £400–£495Eternal Glow 2-session package £400; Radiant Living neck £495 for 2. |
| Neck | Commonly around £240–£450 per sessionRadiant Living neck single £240; combined face/neck courses cost more. |
| Scalp / hair polynucleotides | Commonly around £250–£450 per sessionHair indication priced separately on some clinic menus. |
What affects the price
Brand and formulation
Plinest, Nucleofill, Ameela, Newest and other brands are priced differently.
Treatment area
Under-eye sessions often cost less than full-face or neck-décolletage combinations.
Course length
Most clinics recommend 2–4 sessions spaced 2–4 weeks apart for skin quality results.
Combination with other injectables
Some clinics bundle polynucleotides with skin boosters or Profhilo at package rates.
Practitioner and location
London doctor-led clinics typically sit above regional independent menus.
Why can Modelow appointments cost less?
Some clinics offer reduced-price appointments when they need a model for training, demonstrations, content or supervised practice. The lower price reflects the appointment type — not necessarily lower standards.
Prices change and differ between clinics. Confirm the exact treatment, practitioner, inclusions and total cost before you book.
Sources: Advertised UK clinic prices reviewed September 2026 (8 providers). Research date: September 2026.
What are polynucleotides?
Polynucleotides are injectable biostimulators derived from filtered DNA fragments. Brands such as Plinest, Nucleofill, Ameela and Kiara Reju are used to support skin repair, hydration and collagen activity.
They differ from hyaluronic acid fillers and from Profhilo's specific formulation — though all sit in the injectable skin quality space.
Common uses
Facial skin quality, periorbital (under-eye) rejuvenation, neck laxity and scalp/hair support are the most advertised indications.
Under-eye treatment is a particularly common entry point because polynucleotides are often chosen where traditional filler carries higher risk.
Typical treatment protocol
Most clinics recommend 2–4 sessions spaced 2–4 weeks apart, then maintenance as needed. Each session takes around 30–45 minutes.
Mild swelling or small bumps at injection points usually settle within days.
Why might model appointments cost less?
Training academies increasingly include polynucleotides in model menus alongside fillers and Profhilo. Confirm brand, area treated and supervision.
Frequently asked questions
- Are polynucleotides the same as skin boosters?
- They overlap in purpose — improving skin quality — but use different active ingredients and mechanisms. Some clinics offer both and can explain which suits your concern.
- Can polynucleotides help hair loss?
- Some clinics offer scalp polynucleotide protocols for thinning hair. Evidence and results vary; a consultation should clarify realistic expectations versus PRP or SMP.
- How many sessions do I need?
- Most protocols start with 3 sessions. Your clinic should recommend a course based on area and concern.
- How do I find polynucleotides for less on Modelow?
- Modelow helps you discover reduced-rate model appointments when clinics offer them. Visit Modelow to explore what is available.
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Find polynucleotides for less
Discover aesthetic treatments for less with Modelow. Discover discounted treatments and model appointments at verified clinics across the UK.